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Carolina Panthers at Indianapolis Colts odds, picks and best bets

22nd December, 13:32

The Carolina Panthers (5-9) and Indianapolis Colts (6-8) tangle at Lucas Oil Stadium Sunday at 1 p.m. ET (on CBS). We analyze the Panthers-Colts sports betting odds and lines, with NFL betting picks and tips for the Week 16 matchup.

Panthers at Colts: Week 16 preview, betting trends and notes

Get some action on the game at BetMGM by placing a sports bet! The Panthers turn to rookie QB

Will Grier for his first NFL start. The Colts enter on a four-game losing skid, while going 0-2-1 ATS across the past three games, and 2-5-1 ATS over the previous eight. Indianapolis is 2-2 straight up and 1-3 ATS across the past four games at Lucas Oil Stadium. Colts QB Jacoby Brissett and the offense was limited to a season-low seven points - scored late in the fourth quarter - in Monday's ugly 34-7 loss at the New Orleans Saints. The Colts defense is allowing 34.3 points per game across the past three outings as the Over has hit in two of those contests. Indianapolis ranks ninth in the NFL against the run, allowing just 100.9 yards per game. That will be a key matchup, as they try and slow down Panthers RB Christian McCaffrey. Panthers at Colts: Key injuries

Panthers: WR Curtis Samuel (knee) is questionable, while LB Sha'Quille Thompson (ankle) and DT Vernon Butler (illness) are out.

Colts: DT Denico Autry (concussion), CB Kenny Moore II (ankle), CB Quincy Wilson (shoulder) S Malik Hooker (hand) are out.

Panthers at Colts: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated Saturday at 1:30 p.m. ET.

Prediction

Colts 23, Panthers 20

Moneyline (?)

The Colts (-286) are heavily favored at home, but if you can trust their offense after what you saw last week, you have a lot more betting chutzpah than I do. The Panthers are +225.

New to sports betting? Every $2.86 wagered on the Colts ML will profit $1 if they win.

Against the Spread (?)

The PANTHERS (+7.5, -143) haven't been playing well, but they'll have the best player on the field in McCaffrey. He will be a difference maker and will help take a huge amount of pressure off of Grier in the QB's first NFL start.

Every $1.43 wagered on the Panthers here will profit $1 if they don't lose by 8 or more points or win outright.

Over/Under (?)

PASS. The total of 45.5 (-125 Over, +105 Under) is too close to call in this one. There are a lot of unknowns with Grier running the show, along with the Colts offense looking pretty shabby last week. If there is a lean, it's to the Under - but ever so slightly.

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