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Louisville at Kentucky odds, picks and best bets

29th November, 11:28

The Louisville Cardinals (7-4, 5-3 ACC) hook up with the Kentucky Wildcats (6-5, 3-5 SEC) in Week 14 of the college football season. Kickoff is set for Saturday at 12 p.m. ET at Kroger Field in Lexington, KY. We analyze the Louisville-Kentucky odds and betting lines, while providing college football betting tips and advice on this matchup.

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Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated Thursday at 10:30 a.m. ET.

Louisville 28, Kentucky 27

Louisville enters the week with back-to-back wins, 56-34 over Syracuse and 34-20 over NC State. Kentucky has also won two straight, 50-7 over TN-Martin and 38-14 against Vanderbilt. The Wildcats are 5-2 in Lexington while the Cardinals are 3-2 on the road.

Kentucky (-161) is the favorite at home to retain the Governor's Cup and clinch the winning season, but LOUISVILLE (+135) is getting too much value to be ignored. The Cardinals have the edge in the quarterback battle and will come away with the road victory.

New to sports betting? A $10 bet on the Cardinals to win outright returns a profit of $13.50.

Kentucky is 8-3 against the spread and covers the line by an average of 4.2 points per game. Louisville is 7-4 ATS overall and covers by an average of 3.4 points per game, but slips to 2-2 ATS on the road while falling an average of 0.9 points shy of the cover.

While liking Louisville for the outright win, the safe play is backing CARDINALS (+3.5, -115) to keep this one within a field goal in the event of a loss. The same $10 bet on Louisville returns a profit of $8.70 should it lose by three or fewer points or win outright.

Take the OVER 52.5 (-115) in a final-week shootout. Louisville is 6-5 against the Over/Under and tops the projections by an average of 10.1 PPG. The last five head-to-head meetings each topped this number with ease.

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